Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Using tissue cell culture to make a protein or polypeptide
Patent
1982-09-27
1984-07-31
Shapiro, Lionel M.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Using tissue cell culture to make a protein or polypeptide
C12P 2102, C12N 120, C12R 1465
Patent
active
044630921
ABSTRACT:
Antibiotic A53868 factor A, which is N.sup.2 -glycyl-N-(2-methylene-2-phosphonoethyl)leucinamide, and the formula: ##STR1## and the salts thereof, which are useful as antibiotics or as intermediates to antibiotics; methods of preparing A53868 factor A by fermentation of Streptomyces luridus; and the microorganism S. luridus NRRL 15101.
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K. Hemmi et al., "Studies on Phosphonic Acid Antibiotics. IV. Synthesis and Antibacterial Activity of Analogs of 3-(N-Acetyl-N-Hydroxyamino)Propylphosphinic Acid (FR-900098)", Ibid, 30 (1), 111-118 (1982).
Johnson Ronald D.
Kastner Ralph M.
Larsen Stephen H.
Ose Earl E.
Eli Lilly and Company
Harrison Nancy J.
Shapiro Lionel M.
Whale Arthur R.
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