Process for producing yttrium-90-labelled protein substrate

Details Process for producing yttrium-90-labelled protein substrate Process for producing yttrium-90-labelled protein substrate

1996-04-10

1999-05-11

Tucker, Philip

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Attached to antibody or antibody fragment or immunoglobulin;...

424 111, 424 169, 534 10, 250432PD, 423 2, A61K51/00

Patent

active

059025662

ABSTRACT:
A process for the production of yttrium-90, generated by radioactive decay of strontium-90, by means of a generator including a column containing strontium-90 adsorbed on a cation-exchange resin, wherein yttrium-90, the decay product of strontium-90, is obtained by the flow of an eluent through the resin column of the generator, an acetate buffer solution being used as the eluent. The process enables a solution to be obtained which is usable directly for labelling protein substrates, particularly monoclonal antibodies, with yttrium-90.

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patent: 5729821 (1998-03-01), Knapp et al.
patent: 5744119 (1998-04-01), Phillips
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J. Nucl Med 28; 1465-1470, 1987.
European Journal of Nuclear Medicin, vol. 15, No. 6, 1989.

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