Process for producing valproic acid

Details Process for producing valproic acid Process for producing valproic acid

1997-10-01

1999-01-05

Ambrose, Michael G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C07C 53128

Patent

active

058565698

ABSTRACT:
A process for making valproic acid from an alkyl alkanoylacetate is disclosed. The alkyl alkanoylacetate is reacted with an n-propyl halide in a biphasic system in the presence of a base and a phase transfer catalyst. The product mixture is acidified to convert the resulting valproate salt into valproic acid.

REFERENCES:
patent: 3325361 (1967-06-01), Eugene et al.
patent: 4155929 (1979-05-01), Chignac et al.
patent: 5101070 (1992-03-01), Yamamoto et al.
patent: 5344975 (1994-09-01), Zeiler
patent: 5672746 (1997-09-01), Nau et al.
Database CAPLUS on STN.RTM. International, Chemical Abstracts Service, (Columbus, Ohio), Accession No. 1990:590753, Zydzil et al. PL 136499 B1, Nov. 30, 1987, abstract, 1990.

Affiliated with

Also associated with

Rating

Process for producing valproic acid does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for producing valproic acid, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for producing valproic acid will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-864314