Process for producing tripeptides

Details Process for producing tripeptides Process for producing tripeptides

2006-02-07

2006-02-07

Lilling, Herbert J. (Department: 1651)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Enzymatic production of a protein or polypeptide

C424S093450, C435S252900

Reexamination Certificate

active

06994987

ABSTRACT:
A process for efficiently, easily and stably producing tripeptides Val-Pro-Pro and Ile-Pro-Pro, which are useful as hypotensive drugs, anti-stress drugs, etc., by an enzymatic method. This process involves the step of cleaving a milk casein-containing material with a proteinase to form an intermediate peptide selected from the group consisting of a peptide containing the sequence Val-Pro-Pro but having no Pro other than this sequence, a peptide containing the sequence Ile-Pro-Pro but having no Pro other than this sequence, and a mixture of these peptides, and then cleaving the intermediate peptide with a peptidase to thereby give at least one of the tripeptides Val-Pro-Pro and Ile-Pro-Pro.

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