Process for producing trans-L-hydroxyproline

Details Process for producing trans-L-hydroxyproline Process for producing trans-L-hydroxyproline

1992-11-06

1994-11-15

Knode, Marian

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing alpha or beta amino acid or substituted amino acid...

4352521, 435873, 435822, C12P 1324

Patent

active

053647750

ABSTRACT:
The present invention provides a process for producing trans-L-hydroxyproline, which comprises culturing a microorganism which is capable of decomposing amino acids other than trans-L-hydroxyproline but which is substantially incapable of decomposing trans-L-hydroxyproline in a culture medium containing collagen hydrolyzate, and recovering trans-L-hydroxyproline from the resulting culture.
The process enhances the content of trans-L-hydroxyproline based on the total weight of amino acids contained in collagen hydrolyzate, and enables efficient production of trans-L-hydroxyproline which is useful as a starting material for the synthesis of medicines.

REFERENCES:
Bergey's Manual of Systematic Bacteriology vol. 1 1984 pp. 491, 494.
Singer et al. J of Bacteriology 1955 69:303-306.
Bernheim et al. J of Biol Chem 1935 110:165-172.
Stumpf et al. J of Biol Chem 1944 153:387-399.
Eguchi et al.; Bull. Chem. Soc. Japan, vol. 47(7), 1704-08 (1974).
Kyun Lee et al.; Bull. Chem. Soc. Japan, vol. 46, 2924-2926 (1973).
Ramaswamy et al.; J. Org. Chem., vol. 42, No. 21, 1977, pp. 3440-3443.

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