Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing alpha or beta amino acid or substituted amino acid...
Reexamination Certificate
2007-07-03
2007-07-03
Nashed, Nashaat T. (Department: 1656)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing alpha or beta amino acid or substituted amino acid...
C435S189000, C435S252330, C435S254100, C536S023200, C536S023100
Reexamination Certificate
active
10610561
ABSTRACT:
The present invention is directed to a process for producing trans-4-hydroxy-L-proline, which is useful as a raw material for medicines or as an additive to foods. In the process, L-proline is converted into trans-4-hydroxy-L-proline in the presence of an enzyme source which is derived from a microorganism belonging to the genusDactylosporangium, AmycolatopsisorStreptomycesand which catalyzes the hydroxylation of L-proline into trans-4-hydroxy-L-proline, a divalent iron ion and 2-ketoglutaric acid, in an aqueous medium, and the produced trans-4-hydroxy-L-proline is collected from the aqueous medium. In addition, the present invention is directed to a process for producing trans-4-hydroxy-L-proline, wherein the L-proline biosynthesis activity of the host cell of the transformant is reinforced.
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Ando Katsuhiko
Chiba Shigeru
Mori Hideo
Ozaki Akio
Shibasaki Takeshi
Antonelli, Terry Stout & Kraus, LLP.
Kyowa Hakko Kogyo Co. Ltd.
Nashed Nashaat T.
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