Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1975-10-21
1977-07-12
Brown, Johnnie R.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 17, 536115, C07H 1708
Patent
active
040355675
ABSTRACT:
A process is provided for producing amphotericin B methyl ester wherein amphotericin B is initially mixed and suspended in dimethylformamide or hexamethylphosphoric triamide for a predetermined period, and thereafter aqueous ammonia is slowly added to the mixture until a clear solution is obtained. The dissolved amphotericin B is then esterified with diazomethane in accordance with conventional procedures.
REFERENCES:
patent: 2908612 (1959-10-01), Dutcher et al.
patent: 3945993 (1976-03-01), Schaffner et al.
Noller "Chemistry of Organic Compounds" 3rd Ed. W. B. Saunders Co., Phila, Pa., 1965, p. 184.
Brown Johnnie R.
E. R. Squibb & Sons Inc.
Levinson Lawrence S.
Rodney Burton
Smith Merle J.
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