Process for producing substituted pyrroles

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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C07D207337

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043742556

ABSTRACT:
A process for the preparation of alkyl 1,4-dimethyl-3-ethoxycarbonylpyrrole-2-acetate compounds by reacting in a solvent in diloweralkyl acetone dicarboxylate, a chloromethyl lower alkyl ketone and an aqueous loweralkylamine in the presence of solids formation inhibiting amount of a lower alkanol having from 1 to about 6 carbon atoms.

REFERENCES:
patent: 3752826 (1973-08-01), Carson
patent: 3865840 (1975-02-01), Carson
patent: 3952012 (1976-04-01), Carson
patent: 4048191 (1977-09-01), Carson
Carson et al., J. Med. Chem., vol. 16, pp. 172-174, (1973).
Hantzsch; Berichte der Deutschen Chemischen Gesellschaft, pp. 1474-1479, (1890).
Fischer et al.; Die Chemie des Pyrroles, pp. 5-6, 233-234, (1943).
Grob et al.; Helv. Chim. Acta.; vol. 36; pp. 49-58, (1953).
Jones et al.; The Chem. of Pyrroles, p. 59, (1977).

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