Process for producing steroid derivatives

Details Process for producing steroid derivatives Process for producing steroid derivatives

1987-09-15

1990-01-02

Sneed, H. M. S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26039725, C07J 900

Patent

active

048911682

ABSTRACT:
A process for producing a steroid compound which is useful as an intermediate for synthesizing plant growth regulators, brassinosteroids, and is represented by the general formula (4): ##STR1## in which R.sub.2 is a methyl or ethyl, and * indicates the binding site of R.sub.1 to a steroid nucleus, or general formula (5): ##STR2## wherein R.sub.1 is as defined above. According to the process disclosed herein, an intermediate for a brassinolide, epibrassinolide, homobrassinolide or derivatives thereof can be produced highly advantageously in the industries.

REFERENCES:
A New Synthesis of Brassino Steroids: Plant Growth Promoting Steroids, Anastasia et al., J. Chem. Soc. (PKI), 1983, pp. 379-381.
Reagents for Organic Chemistry, Fieser et al., (1967), pp. 142-147.
Some Modern Methods in Organic Synthesis (2nd Ed.), Carruthers, (1978), pp. 338-343.
Synthesis and Biological Activity of Brassinolide and its 22B,22B Isomer: Novel Plant-Growth-Promoting Steroids, Thompson et al., Steroids, (1981), vol. 38, pp. 567-579.
John Fried and John A. Edwards, Organic Reactions in Steroid Chemistry, vol. 1, pp. 232-233, (1972).
N. F. Blau and C. G. Stuckwisch, The Reaction of Dimethyl Sulfide with 3,5-Cyclosteroids, J. Org. Chem., 27 (2), p. 370, (1962).
Harold R. Nace, The Reaction of .alpha.- and .beta.-cholestanyl p-toluenesulfonates with Methanol, JACS, vol. 74, p. 5937, (1952).
Steroids, vol. 45, No. 6, Jun. 1985, pp. 561-564.
Chemical Pharmaceutical Bulletin, vol. 32, No. 5, May 1984, pp. 2001-2004.
Chemical Abstracts, vol. 105, No. 17, Oct. 27, 1986, pp. 726-727, Abstract No. 153400s.

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