Process for producing statin and related compounds

Details Process for producing statin and related compounds Process for producing statin and related compounds

1987-09-04

1989-02-07

Lieberman, Paul

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560160, C07C125065

Patent

active

048032921

ABSTRACT:
This invention relates to a process for producing statin having the general formula (I): ##STR1## and related compounds thereof; (wherein R is a C1 to C6 alkyl group, a phenyl group or a C7 to C8 phenylalkyl group and B is a protective group for an amino group).
Recently, the anti-hyproperties of statin, namely the renin inhibitive properties, are attracting general attention.

REFERENCES:
patent: 4397786 (1983-08-01), Evans et al.
patent: 4681972 (1987-07-01), Kaltenbronn et al.
Journal of Antibotics, 1970, vol. 23, pp. 259-363.
Nature, 1983, vol. 303, pp. 81-84.
Journal of Medicinal Chemistry by Rich, D. H., 1985, vol. 28, pp. 263-273.
Translation of 106th Meeting of Japanese Pharmaceutical Assoc., p. 208, issued Mar. 10, 1986.
Journal of Medicinal Chemistry, 1980, vol. 23, pp. 27-33.
Journal of Antibiotics, by H. Morishima et al., 1973, vol. 26, pp. 115-17.
Journal of Organic Chemistry, by W. S. Liu, 1978, vol. 43, p. 754.
Tetrahederan Letters, by P. W. K. Woo, vol. 26, p. 2973.

Affiliated with

Also associated with

Rating

Process for producing statin and related compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for producing statin and related compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for producing statin and related compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1085662