Process for producing simvastatin and/or its derivatives

Details Process for producing simvastatin and/or its derivatives Process for producing simvastatin and/or its derivatives

1999-03-05

2000-08-08

Geist, Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549292, 549373, 560196, C07D30930, C07C 69013

Patent

active

061004073

ABSTRACT:
A process for the production of simvastatin and its analogues that is efficient, economical and convenient involves the use of hydroxyl protected intermediates of formula (III) or (VII). These intermediates allow for direct alkylation of the butyrate side chain followed by deprotection and reformation of the lactone ring. R.sup.1 is hydrogen or methyl; R.sup.2 represents a straight or branched chain alkyl group having 1 to 8 carbon atoms, a cycloalkyl group having 3 to 7 carbon atoms, or an aralkyl group having 1 to 6 carbon atoms in the alkyl chain; R.sup.3 and R.sup.4 each independently represent an alkyl group, an ether group, a thioether group, an aryl group, an aralkyl group, an alkenyl group, a cyclic ether group, or a cyclic thioether group; and R.sup.5 and R.sup.6 each independently represent hydrogen, an alkyl group, an aryl group, an aralkyl group, an alkoxy group, or an ether group.

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patent: 5763653 (1998-06-01), Khanna et al.
Greene, T. W. "Protective Groups in Organic Synthesis" John Wiley & Sons New York, 1981.

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