Process for producing simvastatin and analogs thereof

Details Process for producing simvastatin and analogs thereof Process for producing simvastatin and analogs thereof

1993-11-08

1995-02-28

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

566129, C07D30910

Patent

active

053938933

ABSTRACT:
A process is disclosed for the preparation of simvastatin and its analogs through a novel intermediate (III), which enables a selective .alpha. carbon alkylation of the C-8 acyl side chain.

REFERENCES:
patent: 4444784 (1984-04-01), Hoffman et al.
patent: 4582915 (1986-04-01), Sleteinger et al.
patent: 4820850 (1989-04-01), Verhoeven et al.

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