Process for producing secretory immunoglobulin A preparations

Details Process for producing secretory immunoglobulin A preparations Process for producing secretory immunoglobulin A preparations

1993-09-01

1994-12-06

Schain, Howard E.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

5303871, 530382, 5303905, 5303881, 530861, A61L 218, A61K 3514, A61K 3516, C12N 706

Patent

active

053711963

ABSTRACT:
Secretory immunoglobulin A preparations substantially not containing virus are produced by a process wherein secretory immunoglobulin A which might be contaminated with viruses is (1) heated about 60.degree. C. for about 10 hours, or (2) subjected to the reaction with tri-n-butyl phosphate and a surfactant and the heating as mentioned above, as liquidized form in an aqueous medium, and then polymerized matters are precipitated from the resulting solution by adding polyethyleneglycol thereto.

REFERENCES:
patent: 3415804 (1968-12-01), Polson
patent: 4124576 (1978-11-01), Coval
patent: 4439421 (1984-03-01), Hooper et al.
patent: 4721777 (1988-01-01), Uemura et al.
Labib et al, J. Biol Chem. vol. 251:7, pp. 1969-1974, 1976 Bovine Secretory Component.

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