Process for producing pyrrolidone derivative

Details Process for producing pyrrolidone derivative Process for producing pyrrolidone derivative

1988-02-03

1989-06-06

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D20727

Patent

active

048373370

ABSTRACT:
Disclosed herein is a process for producing a pyrrolidone derivative represent by the general formula (I): ##STR1## wherein R is an organic residue obtained by removing hydroxy radical from a C.sub.1-10 primary alcohol, C.sub.1-10 secondary alcohol or derivative thereof, comprising (1) reacting 2-pyrrolidone with acetaldehyde in the presence of a catalyst, thereby obtaining N-(.alpha.-hydroxyethyl)pyrrolidone, and (2) reacting the thus obtained N-(.alpha.-hydroxyethyl)pyrrolidone with a primary alcohol, a secondary alcohol or a derivative thereof in the presence of an acidic catalyst to obtain the pyrrolidone derivative.

REFERENCES:
patent: 2924606 (1960-02-01), Schroeder et al.
patent: 3853910 (1974-12-01), Freyermuth et al.
patent: 3956313 (1976-05-01), Freyermuth et al.
Organic Reactions, vol. 14, pp. 92-103, ".alpha.-Amidoalkylations at Carbon"(1965).
Bohme und Berg; "Zur Kenntnis de N-[.alpha.Alkoxy-alkyl]-carbonsaureamide . . . ", pp. 2127-2135 (1966).

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