Process for producing purine derivatives

Details Process for producing purine derivatives Process for producing purine derivatives

1997-09-10

1999-08-24

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen bonded directly to ring carbon of the purine ring...

544230, 544265, 544267, 544271, 544272, 544273, 544277, C07D47318, C07D47334, C07D47330, C07D47316

Patent

active

059426179

ABSTRACT:
A process for preparing 7-benzylpurine derivatives is provided. An acetylpurine nucleoside is reacted with a benzyl halide to benzylate the 7-position of the purine base, and an acid is then added to the reaction mixture to hydrolyze the glycoside bond. The 7-benzylpurines may be used to prepare 9-substituted purine derivatives.

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patent: 5625057 (1997-04-01), Shiragami et al.
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Hawley's Condensed Chemical Dictionary, 12th edition, pp. 21-22, 1990.
Brookes et al J. Chem. Soc. (C), 1968, pp. 2026-2028.
Er-Rhaimini Synthesis, 1988, pp. 154-155.
Piper, J. Med. Chem. 23, 357, 1980.

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