Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical
Reexamination Certificate
2007-04-03
2007-04-03
Prouty, Rebecca E. (Department: 1652)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing saccharide radical
C435S069100, C435S320100, C435S254230, C435S193000, C536S023700
Reexamination Certificate
active
10276075
ABSTRACT:
The present invention intends to find out a gene participating in addition of mannose phosphate to a sugar chain of a glycoprotein originating in a yeast belonging to the genusPichiaand provide a means of controlling the same. The present invention also intends to provide a process for producing a protein with reduction of an acidic sugar chain by using the thus controlled yeast strain belonging to the genusPichia. Namely, the present invention includes a protein participating in the addition of mannose phosphate to a sugar chain of a glycoprotein; a gene encoding this protein; a mutant of this gene; a vector carrying the mutant gene; a yeast strain belonging to the genusPichiahaving been transformed by this vector; a process for producing a protein with reduction of an acidic sugar chain by using the transformed yeast strain; and a glycoprotein thus produced.
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Hirose Masaaki
Irie Hiroyuki
Kuwae Shinobu
Miura Masami
Miwa Taeko
Kilyk & Bowersox P.L.L.C.
Meah Mohammad
Mitsubishi Pharma Corporation
Prouty Rebecca E.
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