Process for producing porous, controlled-release capsules and en

Details Process for producing porous, controlled-release capsules and en Process for producing porous, controlled-release capsules and en

1996-09-03

1999-09-28

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424451, 424452, 424456, A61K 952

Patent

active

059584513

ABSTRACT:
The porous capslues were prepared by mechanical drilling, addition of effervescent to gelatin solution, or purging of inert gas into the gelatin solution. The porous capsules were then hardened by exposure to the cross-linking reagent, or by radiating under the UV, or microwave, or .gamma.-Ray. The usage of these porous gelatin capsules apart for pharmaceuticals extends to veterinary, cosmetic, and nutrient purposes. They are also utilized in the delivering of required beneficial agents to the chemical reactor, environment, and for agricultural purposes.

REFERENCES:
patent: 3823816 (1974-07-01), Controulis et al.
patent: 4609403 (1986-09-01), Wittwer et al.
patent: 4719112 (1988-01-01), Mayer et al.
patent: 5466460 (1995-11-01), McMahon et al.
Higuchi, Rate of Release of Medicaments from Ointment Bases Containing Drugs in Suspension, Journal of Pharmaceutical Sciences, vol. 40, p. 874, 1961.
Jain, et al., Design of a Slow-Release Capsule Using Laser Drilling, Journal of Pharmaceutical Sciences, vol. 73, No. 12, p. 1806, 1984.
Quigley et al., Medline, #92309153, 1993.
Graham, Chemical Abstracts, vol. 114, #49582, 1992.
Bauer et al., Chemical Abstracts, vol. 120, #194421, 1994.
Phadke et al., Chemical Abstracts, vol. 116, #241948, 1992.

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