Process for producing polysaccharide ron substance with a synthe

Details Process for producing polysaccharide ron substance with a synthe Process for producing polysaccharide ron substance with a synthe

1993-09-15

1996-10-15

Naff, David M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435183, 4352521, 435822, 536 551, 536124, C12P 1904, C12N 112, C12N 110, C07H 504

Patent

active

055653421

ABSTRACT:
A polysaccharide RON substance which has antitumor activity can be produced by fermenting sucrose with a synthetase. The synthetase can be isolated from Leuconostoc strains. Preferred strains of the microorganism are Leuconostoc mesenteroides FERM BP-2242, 2711, 2712, 2713, 2714, and 2670. The substance exhibits antitumor activity against syngenic tumor Meth A, a transplantable tumor in mice.

REFERENCES:
patent: 4762825 (1988-08-01), Takeo et al.
Chemical Abstracts, vol. 110, No. 1, Jan. 2, 1989, Columbus, Ohio, USA, Takeo Suguru et al., "Studies on an Antitumor Polysaccharide RBS Derived from Rice Bran. II. Preparation and General Properties of RON, an Active Fraction of RBS." p. 392, abstract No. 387w & Chem. Pharm. Bull. 1988, 36(9), 3609-13.
Marina E. Preobrazhenskaya et al, Studies on Some Biologically Active Dextrans, Carbohydrate Research, 66 (1978) pp. 213-223.
S. M. Navashin et al, Antitumor and Antibacterial Activity of Dextran LU-122 and Its Effect on Macrophage Activity, Curr. Chemother. Immunother., Proc. Int. Congr. Chemther, 12th, 1, pp. 190-192 (1982).

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