Process for producing polyesters by fermentation; a process for

Details Process for producing polyesters by fermentation; a process for Process for producing polyesters by fermentation; a process for

1987-12-01

1992-08-04

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing oxygen-containing organic compound

435146, 435136, 435280, 435874, C12P 762, C12P 742, C12P 740

Patent

active

051358590

ABSTRACT:
This invention relates to a process for producing polyester biopolymers by culturing Pseudomonas oleovorans bacteria on substrates comprising certain nutrients. The nature of the polyesters can be varied by varying the nature of the carbon source used. In this way polyesters with unsaturated double bonds can be produced, too. From the polyesters, optically active carboxylic acids or esters are produced. The polymers can be used for making articles of manufacture, such as sutures, films, skin and bone grafts.

REFERENCES:
patent: 4477654 (1984-10-01), Holmes et al.
Huisman, G., et al., App. Env. Microbiol., 55(8), 1949-1954 (1989).
Brandl, H., et al., 1988, "Pseudomonas oleovorans as a Source of Poly (.beta.-Hydroxy alkanoates) for Potential Applications as Biodegradable Polyesters", Applied and Environmental Microbiology vol. 54, pp. 1977-1982.
Ketelaar, P. E. F., et al., 1985, "Assymetric Synthesis of (S)-methyl-3-hydroxyalkanoates from ketene and 2,2-dichloroaldehydes via 4-(1,1-dichloroalkyl)-2-oxetanones", Tetrahedron Letters, vol. 26, pp. 4665-4668.
DeSmet, M. J., et al., 1981, "Synthesis of 1,2-Epoxy octane by Pseudomonas oleovorans during growth in a Two-Phase System containing High Concentrations of 1-Octene", Applied and Environmental Microbiology, vol. 42, pp. 811-816.
De Smet, M. J., et al. 1983, "Characterization of Intracellular Inclusions Formed by Pseudomonas oleovorans During Growth on Octane", Journal of Bacteriology, vol. 154, pp. 870-878.
Lageveen, R. G., et al., 1988, "Formation of Polyesters by Pseudomonas oleovorans: Effect of Substrates on Formation and Composition of Poly-(R)-3-hydroxyalkanoates and Poly-(R)-3-Hydroxyalkenoates", Applied and Environmental Microbiology, vol. 54, pp. 2924-2932.
Suzuki, T., et al., 1986, "Mass production of poly-.beta.-hydroxybutyric acid by fully automatic fed-batch culture of methylotroph", Applied Microbiology and Biotechnology, vol. 23, pp. 322-329.
De Smet et al., Enzyme and Microbial Technology, vol. 5, 352-360 (1983).
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