Process for producing phosphine oxide vitamin D precursors

Details Process for producing phosphine oxide vitamin D precursors Process for producing phosphine oxide vitamin D precursors

2008-05-29

2011-10-18

Saeed, Kamal (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus containing

Reexamination Certificate

active

08039676

ABSTRACT:
A process for producing a compound of the formula:including reacting of a compound of the formula:with diphenyl phosphine oxide using a binary phase reaction mixture including diphenyl phosphine oxide in an organic solvent, a basic aqueous solution, and a phase transfer catalyst, to obtain the compound of formula 1,wherein Ph is phenyl, X1and X2are both hydrogen or X1and X2taken together are CH2, R1is a protecting group, R2is fluorine, hydrogen, or OR3, wherein R3is a protecting group, and the squiggly line represents a bond that results in the adjacent double bond being in either the E or Z configuration, is disclosed.

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