Process for producing parasiticidal milbemycin derivatives by cu

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...

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435134, 435 76, 4352535, C12B 1779

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active

056208740

ABSTRACT:
Compounds of formula (I): ##STR1## wherein R.sup.1 is hydrogen or methyl, R.sup.2 is hydrogen or (E)-2-methyl 2-butenoyloxy, and R.sup.3 is hydrogen or hydroxy, with the proviso that when R.sup.3 is hydrogen, R.sup.1 and R.sup.2 are both hydrogen, and when R.sup.2 is (E)-2-methyl 2-butenoyloxy, R.sup.1 is methyl; the compound of formula (II): ##STR2## and the compound of formula (III): ##STR3## are obtainable by the fermentation of Streptomyces E225 NCIB 12310 or Streptomyces E225B NCIB 12509. The compounds have antihelminthic utility.

REFERENCES:
patent: 4093629 (1978-06-01), Fisher
patent: 4144352 (1979-03-01), Putter
patent: 4310519 (1982-01-01), Albers-Schonberg
J. Antibiotics, 29 (3), pp. 76-14-76-16 (1976).
J. Antibiotics, 29(3), pp. 76-35-76-42 (1976).

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