Process for producing oxiracetam

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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C07D20712

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active

046862960

ABSTRACT:
A process for producing oxiracetam (4-hydroxy-2-oxo-1-pyrrolidineacetamide) useful as an agent for improving brain metabolism, under mild conditions and in a single process is provided, this process comprises reacting glycinamide with a butyric acid ester expressed by the formula ##STR1## wherein A represents a halogen atom or an epoxy group, B represents hydroxyl group, but when A is an epoxy group, A and B together form an epoxy group, and R represents an alkyl group.

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patent: 4341790 (1982-07-01), Betzing et al.
Z. Physiol. Chem., 64, pp. 348-366 (1910); Bergell et al.
J. Org. Chem., 32, pp. 3888-3994 (1967); McClure.

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