Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...
Patent
1993-07-12
1995-07-04
Lilling, Herbert J.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing heterocyclic carbon compound having only o, n, s,...
435118, 435822, 435863, 514287, 546 64, A61K 31435, C07D49814, C12P 1718, C12P 1716
Patent
active
054299403
ABSTRACT:
The present invention provides a process for producing oxazopyrroloquinolines which comprises culturing microorganisms to produce pyrroloquinolinequinone and adding .alpha.-amino acids or monomethylamine to the resulting culture broth which contains the pyrroloquinolinequinone and from which cells of microorganisms are not separated, thereby to convert the pyrroloquinolinequinone to the corresponding oxazopyrroloquinolines. The thus obtained oxazopyrroloquinolines include novel compounds. The present invention further provides aldose reductase inhibitors, diabetic combined disease curing agents, immunopotentiating agents and liver disease inhibiting agents which contain as active ingredient these oxazopyrroloquinolines having excellent physiological activity.
REFERENCES:
patent: 4994382 (1991-02-01), Ameyama et al.
Itoh Chieko
Kobayashi Hisao
Nagai Toshio
Oda Mitsunori
Sugamura Kazuhiro
Burke Henry T.
Lilling Herbert J.
Mitsubishi Gas Chemical Company
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