Process for producing orotic acid by fermentation

Details Process for producing orotic acid by fermentation Process for producing orotic acid by fermentation

1988-10-12

1991-05-07

Robinson, Douglas W.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

4352521, 435843, 435861, C12P 1712, C12N 120

Patent

active

050136569

ABSTRACT:
A process is disclosed for producing orotic acid, the process involves culturing in a medium a microorganism of the genus Corynebacterium which is capable of producing orotic acid and has resistance to a pyrimidine analogue or to both a pyrimidine analogue and a sulfa drug, until orotic acid is accumulated in the culture, and recovering orotic acid therefrom.

REFERENCES:
patent: 3086917 (1963-04-01), Kinoshita et al.
Chemical Abstracts, vol. 84, No. 17, Apr. 26, 1976, p. 400, Abstract No. 119951k, Columbus, Ohio, US.
Chemical Abstracts, vol. 73, No. 13, Sep. 28, 1970, p. 220, Abstract No. 65038v, Columbus, Ohio, US.
Herrmann et al., "Amino Acids Biosynthesis and Genetic Regulation", 1983, pp. 415-418, Addison-Wesley.
Stanbury et al., "Principles of Fermentation Technology", 1984, pp. 43-47.
Ozaki et al., "Amino Acid-Nucleic Acid", pp. 24-30, vol. 26, 1972.
Ogata et al., Microbial Production of Nucleic Acid Related Substances, John Wiley, 1976.

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