Process for producing optically active β-amino acid...

Details Process for producing optically active β-amino acid... Process for producing optically active β-amino acid...

2008-04-01

2008-04-01

Puttlitz, Karl (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C560S043000, C560S155000, C562S433000, C562S533000

Reexamination Certificate

active

07351849

ABSTRACT:
The present invention is to provide a method for producing the desired optically active β-amino acid derivatives of high optical purities in high yields, without requiring a step of deprotection. More particularly, the present invention relates to a method for producing an optically active β-amino acid derivative or a salt thereof represented by the formula (2):which comprises reacting an α,β-unsaturated carboxylic acid derivative or a salt thereof represented by the formula (1):with an amines or a salt thereof in the presence of a chiral catalyst and in the presence or absence of an acid.

REFERENCES:
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Y. Hamashima et al., “Amine-Salt-Controlled, Catalytic Asymmetric Conjugate Addition of Various Amines and Asymmetric Protonation”, Organic Letters, vol. 6, No. 11, pp. 1861-1864, May 27, 2004.
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M. P. Sibi et al., “Chiral Lewis Acid Catalysis in Conjugate Additions ofO-Benzylhydroxylamine to Unsaturated Amides. Enantioselective Synthesis of β-Amino Acid Precursors”, J. Am. Chem. Soc., vol. 120, No. 26, pp. 6615-6616, 1998.

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