Process for producing optically active hydroxy lactones

Details Process for producing optically active hydroxy lactones Process for producing optically active hydroxy lactones

1990-12-12

1992-01-28

Ivy, C. Warren

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

435125, 435126, 435135, 549292, 549313, C12P 4100

Patent

active

050843923

ABSTRACT:
The invention provides a method for producing an optically active hydroxy lactone which comprises reacting under substantially anhydrous conditions and in the presence of an enzyme an ester and a racemic compound represented by the general formula (I): ##STR1## wherein n is 0 or 1, any one of R.sup.1 and R.sup.2 is a hydroxy group, and R.sup.2 =R.sup.3 =H or R.sup.2 =R.sup.3 =CH.sub.3 when R.sup.1 is the hydroxy group, and R.sup.1 =R.sup.3 =H when R.sup.2 is the hydroxy group, to effect a transesterification reaction, and resolving to an optically active alcohol which has R- or S-configuration and the ester of the symmetric alcohol.

REFERENCES:
patent: 4489208 (1984-12-01), Olivieri et al.
patent: 4916074 (1990-04-01), Yoshida et al.
patent: 4962031 (1990-10-01), Yoshida et al.
patent: 4971909 (1990-11-01), Kaneoya et al.
Mori et al., Tetrahedron, 35, 933 (1979).
Hayashi et al., J. Am. Chem. Soc., 95, 8749 (1973).
Luk et al., Synthesis, 3, 226 (1988).
Seebach, Synthesis, 1, 37 (1986).
Meyers, Tetrahedron Letters, 29, 5617 (1988).
Bevinakatti, J. Org. Chem., 54, 2453 (1989).

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