Process for producing optically active halohydrin compound

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Reexamination Certificate

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06888012

ABSTRACT:
A process of preparing an optically active halohydrin compound characterized by comprising asymmetric hydrogen transfer reduction of an α-haloketone compound in the presence of a group 9 transition metal compound having a substituted or unsubstituted cyclopentadienyl group and an optically active diamine compound. The asymmetric hydrogen transfer reduction is preferably conducted in the presence of a base.

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Journal of Organic Chemistry, vol. 64, pp. 2186-2187 1999.
T. Thorpe et al.: “Efficient rodium and iridium-catalysed asymmetric transfer hydrogenation using water-soluble aminosulfonamide ligands” Tetrahedron Letters, vol. 42, pp. 4041-4043, 2001.

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