Process for producing optically active flurbiprofen

Details Process for producing optically active flurbiprofen Process for producing optically active flurbiprofen

2007-05-08

2007-05-08

Page, Thurman K. (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

Reexamination Certificate

active

10543186

ABSTRACT:
The present invention provides a method for producing optically active flurbiprofen. The method of the present invention includes mixing racemic flurbiprofen and (S)- or (R)-3-methyl-2-phenylbutylamine in an organic solvent to produce a diastereomeric salt; and treating the diastereomeric salt with an acid in a second solvent. In the method of the present invention, flurbiprofen having a desired absolute configuration can be obtained very efficiently without repeating the procedure for optical resolution a plurality of times.

REFERENCES:
patent: 3755427 (1973-08-01), Adams et al.
patent: 3959364 (1976-05-01), Armitage et al.
patent: 4209638 (1980-06-01), Nicholson et al.
patent: 5190981 (1993-03-01), Wechter
patent: 5599969 (1997-02-01), Hardy et al.
patent: 0 703 212 (1996-03-01), None
patent: 1 596 032 (1981-08-01), None
patent: 54-154724 (1979-12-01), None
patent: 8-319252 (1996-12-01), None
patent: 94/12460 (1994-06-01), None
patent: 96/23759 (1996-08-01), None

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