Process for producing optically active compounds

Details Process for producing optically active compounds Process for producing optically active compounds

1987-10-28

1990-04-10

Rosen, Sam

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

435134, 435135, C12P 4100

Patent

active

049160745

ABSTRACT:
The present invention provides a process for producing optically active compounds by a biochemical method in which specific compounds having hydroxyl groups are reacted with esters in the presence of enzymes. The compounds have the following general formula. ##STR1## wherein Y is selected from the group consisting halogen atoms, alkyl groups having 1-3 carbon atoms, cyano groups, and trifluoromethyl groups, W is selected from the group consisting substituted phenyl groups, and halogen atoms, cyano, trifluoromethyl and amino groups and alkylamino and alkyloxycarbonyl groups in which alkyl groups have 1-20 carbon atoms, R is methylene and n is 0 or 1.
The enzymes having ability of transesterification reaction is preferably lipase, lipoprotein lipase, esterase and so on, and micro-organisms can be used in the above process.

REFERENCES:
patent: 4451565 (1984-05-01), Gatfield et al.
Cambou et al.-Annals of N.Y. Acad. Science, vol. 434 (1984), pp. 219-222.
Cambou et al.-J.A.C.S., vol. 106 (1984), pp. 2687-2692.
Kirchner et al.-J.A.C.S., vol. 107 (1985), pp. 7072-7076.
Derwent Abstract-Japanese Patent-63-123399 (May 27, 1988).

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