Process for producing optically active carboxylic acid amide

Details Process for producing optically active carboxylic acid amide Process for producing optically active carboxylic acid amide

1994-05-16

1995-12-19

Marx, Irene

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

435131, 435170, 435822, C12P 900

Patent

active

054767911

ABSTRACT:
N-(3-acetylthio-2-D-methylpropionyl)-L-proline useful as a precursor of captopril, one of antihypertensive agents, is prepared by allowing thioacetic acid to react with methyl methacrylate to prepare racetalc methyl 3-acetylthio-2-DL-methylpropionate, contacting the propionate with cells of, for example, Pseudomonas in order to effect biological and asymmetric hydrolysis, extracting 3-acetylthio-D-2-methylpropionic acid and allowing the acid to react with L-proline.

REFERENCES:
patent: 4154935 (1979-05-01), Oudehi
patent: 4415657 (1983-11-01), Umezawa et al.
patent: 4584270 (1986-04-01), Sih
Goodfellow et al, "The Biology of the Actinomycetes", pp. 92-93, 1984, Academic Press, The ATCE Catalogue of Yeasts, 1990, p. 9.

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