Process for producing optically active .beta.-hydroxyketone

Details Process for producing optically active .beta.-hydroxyketone Process for producing optically active .beta.-hydroxyketone

1994-03-10

1995-07-18

Siegel, Alan

Organic compounds -- part of the class 532-570 series

Organic compounds

Esters having the thiocarboxylate group, -cx-, wherein the...

560 55, 560145, 560179, 560184, 560185, 568315, 568317, 568391, 568394, 568395, C07C32700, C07C 6976, C07C 4500

Patent

active

054342899

ABSTRACT:
A process for producing an optically active .beta.-hydroxyketone represented by formula (I): ##STR1## by catalytic asymmetrical aldol reaction is disclosed, comprising reacting a silyl-enol ether represented by formula (II): ##STR2## with a substituted aldehyde represented by formula (III):

REFERENCES:
Chemistry Letters, (1990) pp. 1015-1018.
Synlett (Jun. 1991), pp. 439-440.
Tetrahedron Letters, vol. 33, No. 13, pp. 1729-1732 (1992).
J. Am. Chem. Soc. 1992, 114, pp. 4418-4420.
Chemistry and Industry, 1 Dec. 1986, p. 824.
J. Am. Chem. Soc. 1991, 113, pp. 9365-9366.
J. Am. Chem. Soc., 1993, 115, pp. 7039-7040.

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