Process for producing optically active azetidine-2-carboxylic ac

Details Process for producing optically active azetidine-2-carboxylic ac Process for producing optically active azetidine-2-carboxylic ac

1998-01-23

2000-12-19

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

C12P 1710

Patent

active

06162621&

ABSTRACT:
There is provided a process for producing N-substituted azetidine-.2-carboxylic acid of the formula I: ##STR1## wherein R.sup.1 denotes an aralkyl group or an arylated lower alkoxycarbonyl group and * designates an asymmetric carbon atom, which is characterized by:
reacting an N-substituted azetidine-2-carboxylic acid ester of the formula II: ##STR2## wherein R.sup.1 has the same meaning as defined above and R.sup.2 denotes an alkyl group, an aralkyl group or an allyl group, with an enzyme capable of selectively hydrolyzing a stereoisomer based on the carbon atom of the 2-position of the azetidine ring.

REFERENCES:
Rodebaugh et al., J. Heterocyclic Chemistry, vol. 6, No. 6, pp. 993-994 (Dec. 1969).
Kozikowski et al., J. Med. Chem., 1993, 36, 2706-2708.
D. Seebach et al., Liebigs Ann. Chem., 687-695 (1990).

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