Process for producing optically active aryloxypropionic acids an

Details Process for producing optically active aryloxypropionic acids an Process for producing optically active aryloxypropionic acids an

1984-07-26

1986-02-04

Rosen, Sam

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

435119, 435120, 435121, 435128, 435130, 435135, 435136, 435141, 435146, 435280, C12P 1712, C07P 4100

Patent

active

045686416

ABSTRACT:
A process for the stereospecific inversion of the [S] enantiomer of an .alpha.-aryloxypropionic acid of formula I: ##STR1## wherein G is OR.sup.1 or ##STR2## R.sup.1 is hydrogen or a protecting group and R.sup.2 is hydrogen or methyl, U and V each independently represent hydrogen or halogen, and R is a carboxyl group, or an enzymic equivalent thereof, which process comprises contacting said [S] enantiomer with a microorganism having a stereospecific inverting enzyme system, or with an extract of the microorganism contacting said enzyme system, to convert the [S] enantiomer to the corresponding [R] enantiomer.

REFERENCES:
patent: 4204044 (1980-05-01), Suhara et al.
patent: 4443548 (1984-04-01), Oshima et al.
patent: 4461835 (1984-07-01), Sih
Hutt et al., J. Pharm. Pharmacol., 1983, 35, 693-704.

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