Process for producing optically active amino acids

Details Process for producing optically active amino acids Process for producing optically active amino acids

1989-08-22

1992-01-14

Robinson, Douglas W.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing alpha or beta amino acid or substituted amino acid...

435109, 435110, 435280, 435227, 435228, 4352521, 4352525, 435833, 435850, 435829, 435824, 435883, 435827, 435907, 435881, C12P 1304, C12P 1320, C12P 1314, C12N 978

Patent

active

050810243

ABSTRACT:
An efficient process of optical resolution is provided for producing an L-amino acid represented by the following formula (I): ##STR1## wherein R is --CH.sub.2 CO.sub.2 H, --CH.sub.2 CONH.sub.2, --CO.sub.2 H or ##STR2## in which R.sup.1 is hydrogen atom, an alkyl group having 1 to 10 carbon atoms or a halogen-substituted alkyl group having 1 to 10 carbon atoms. The process comprises an optical resolution of an N-substituted carbonyl-D,L-amino acid represented by the formula (II): ##STR3## (wherein R is the same as defined above and R.sup.2 is an alkanoyl group having 1 to 5 carbon atoms, benzoyl group, a halogen-substituted alkanoyl group having 1 to 5 carbon atoms or a halogen-substituted benzoyl group), its salt or a mixture thereof, by means of cells of a microorganism, a fermentation broth of a microorganism, a treated fermentation broth of a microorganism or a mixture thereof, said microorganism being selected from the bacteria of the genera Serratia, Staphylococcus, Bacillus, Flavobacterium, Achromobacter and Alcaligenes and actinomycetes of the genera Actinoplanes, Streptosporangium and Sebekia.

REFERENCES:
patent: 3816254 (1974-06-01), Chibata
patent: 3963573 (1976-06-01), Stauffer
patent: 4226941 (1980-10-01), Goi et al.
patent: 4389488 (1983-06-01), Grabley et al.
Bergey's Manual of Determinative Bacteriology, Eighth Edition, 1974, pp. 326-327, 483 and 707.
Bergey's Manual of Determinative Bacteriology, Eighth Edition, 1984, pp. 356, 363-365.
Chemical Abstracts, vol. 90, No. 13, 3/26/79, pp. 436-437, Abstract No. 10196c, Yakuhin.

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