Process for producing optically active .alpha.-substituted organ

Details Process for producing optically active .alpha.-substituted organ Process for producing optically active .alpha.-substituted organ

1991-11-27

1994-02-01

Lee, Lester L.

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

C12P 740

Patent

active

052831930

ABSTRACT:
A process for producing an optically active .alpha.-substituted organic acid represented by formula (II), comprising the steps of (a) treating a racemic substituted nitrile or amide represented by formula (I) with a microorganism selected from the group consisting of the microorganisms of genuses Alcaligenes, Pseudomonas, Rhodopseudomonas, Corynebacterium, Acinetobacter, Bacillus, Mycobacterium, Rhodococcus and Candida, or preparations thereof; and (b) recovering the resulting optically active u-substituted organic acid represented by formula (II): ##STR1## wherein R.sub.1 and R.sub.2 each represent a halogen atom, a hydroxyl group, a substituted or unsubstituted alkyl group, a substituted or unsubstituted cycloalkyl group, a substituted or unsubstituted alkoxy group, a substituted or unsubstituted aryl group, a substituted or unsubstituted aryloxy group or a substituted or unsubstituted heterocyclic group with the proviso that R.sub.1 and R.sub.2 are different from each other; and X represents a nitrile group or an amido group, ##STR2## wherein R.sub.1 and R.sub.2 are as defined above.

REFERENCES:
patent: 4080259 (1978-03-01), Boesten et al.
patent: 4443548 (1984-04-01), Oshima et al.
patent: 4812403 (1989-03-01), Boesten et al.
Fukuda, Y. et al, J. Ferment. Technol., 51:393-397 (1973).

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