Process for producing optically active .alpha.-hydroxyesters usi

Details Process for producing optically active .alpha.-hydroxyesters usi Process for producing optically active .alpha.-hydroxyesters usi

1991-05-31

1993-09-28

Robinson, Douglas W.

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

435876, C12P 722

Patent

active

052486109

ABSTRACT:
The invention provides a process for producing an optically active .alpha.-hydroxyester by a biochemical method, and the process comprises reacting an ester with a racemic compound in the presence of a lipase to obtain the following compound which are useful for starting materials for physiological active materials, functional materials and the like. ##STR1## wherein R is alkyl of 1-5 carbon atoms, A is alkyl of 1-20 carbon atoms, perfluorophenyl, 2-phenylethyl or a specific phenyl group.

REFERENCES:
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Fitzpatrick, J. Am. Chem. Soc. 113:3166-71 (1991).
Hsu et al, Tetrahedron Lett. 31:6403-6406 (1990).
Wang et al, J. Am. Chem. Soc. 110:7200-7205 (1988).
Bianchi D, J. Org. Chem 53:5531-34 (1988).
Klibanov A, Acc. Chem. Res. 23:114-120 (1990).
Okumura S, BBA 575:156-165 (1979).
Hills M, BBA 1042:237-240 (1990).

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