Process for producing optically active .alpha.-hydroxycarboxylic

Details Process for producing optically active .alpha.-hydroxycarboxylic Process for producing optically active .alpha.-hydroxycarboxylic

1996-12-12

1998-02-03

Saucier, Sandra E.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing oxygen-containing organic compound

435280, C12P 742

Patent

active

057143579

ABSTRACT:
A biological process for predominantly producing an optically active .alpha.-hydroxycarboxylic acid having a phenyl group directly from a racemic .alpha.-hydroxynitrile or a mixture of an aldehyde corresponding to the nitrile and prussic acid as a substrate is disclosed, comprising reacting a microorganism belonging to the genus Rhodococcus, Alcaligenes, Brevibacterium or Pseudomonas with the substrate in a neutral to basic aqueous medium. A desired optically active .alpha.-hydroxycarboxylic acid having a phenyl group can be obtained quantitatively at a high optical purity.

REFERENCES:
patent: 5223416 (1993-06-01), Endo et al.
patent: 5283193 (1994-02-01), Yamamoto et al.
patent: 5326702 (1994-07-01), Endo et al.
Applied and Environmental Microbiology, vol. 57, No. 10 pp. 3028-3032 (1991).

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