Organic compounds -- part of the class 532-570 series – Organic compounds – Oxygen containing
Patent
1987-06-25
1990-10-09
Evans, J. E.
Organic compounds -- part of the class 532-570 series
Organic compounds
Oxygen containing
502162, 568875, 568903, C07C 2917, C07C 31125, C07C 31135, C07C 33025
Patent
active
049622420
ABSTRACT:
A process for producing an optically active alcohol represented by formula (I): ##STR1## wherein R.sub.1 is an alkyl group having from 2 to 11 carbon atoms, an alkenyl group having from 3 to 11 carbon atoms, an alkadienyl group having from 6 to 11 carbon atoms, a cyclohexyl group, an cyclohexylmethyl group, or a cyclohexylethyl group, provided that the olefin in the alkenyl group or alkadienyl group is not conjugated to the olefin at the 2-position thereof; and * means an asymmetric carbon atom,
is disclosed, comprising subjecting an olefinic alcohol represented by formula (II): ##STR2## wherein R.sub.1 is the same as defined above to asymmetric hydrogenation in the presence of, as a catalyst, a ruthenium-optically active phosphine complex.
According to the process of the invention, the desired optically active alcohols which are useful not only as intermediates for the manufacture of perfumes and vitamin E but also as liquid crystal materials can be produced with high optical purities.
REFERENCES:
patent: 3849480 (1974-11-01), Knowles et al.
patent: 3857900 (1974-12-01), Wilkinson
patent: 4117016 (1978-09-01), Hughes
patent: 4338479 (1983-06-01), Gryaznov et al.
patent: 4691037 (1987-09-01), Yoshikawa et al.
Inoue et al., "Asymmetric Hydrogenation of Geraniol, Etc.," Chemistry Letterrs, pp. 1007-1008 (1985).
Ikariya et al., "Synthesis of Novel Chiral Ruthenium Complexes, Etc.," J. Chem. Soc., Chem. Commun., pp. 922-924 (1985).
Takaya et al., "Enantioselective Hydrogenation of Allylic, Etc.," J. Amer. Chem. Soc'y, vol. 109, pp. 1596-1597 (Mar., 1987).
Journal of The Chemical Society, Chemical Communications, 1985, pp. 922-924, The Royal Chemical Society, London, GB; T. Ikariya et al.: "Synthesis of Novel Chiral Ruthenium Complexes of . . . Catalysts".
Chemistry Letters, No. 7, 1985, pp. 1007-1008, The Chemical Society of Japan, Tokyo, JP; Shin-Ichi Inoue et al: "Asymmetric Hydrogenation of Geraniol and Nerol Catalyzed by BINAP-Rhodium (I) Complexes".
Akutagawa Susumu
Inoue Shin'ichi
Kumobayashi Hidenori
Noyori Ryoji
Sayo Noboru
Evans J. E.
Takasago Perfumery Co. Ltd.
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