Process for producing optically active alcohol containing phenyl

Details Process for producing optically active alcohol containing phenyl Process for producing optically active alcohol containing phenyl

1995-09-15

1997-02-04

Barts, Samuel

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

C07C 2974

Patent

active

056000278

ABSTRACT:
A process for producing an optically active alcohol having a phenyl group is disclosed, comprising the step of carrying out interesterification between (a) a monoester between a racemic alcohol having a phenyl group and a fatty acid or a diester between a racemic alcohol having a phenyl group and a dibasic acid and (b) an optically inactive non-racemic alcohol having 16 or more carbon atoms in the presence of heat-resistant lipase and in the absence of a solvent under a substantially water-free condition at a temperature of not lower than 81.degree. C. under atmospheric pressure or reduced pressure and the step of separating an optically active alcohol having a phenyl group rich in either one of R- and S-forms from the reaction mixture. Use of heat-resistant lipase makes it possible to use high-melting point materials without using any solvent therefor and to perform interesterification at a high temperature thereby completing the reaction in a reduced time. Further, use of a high-melting point and high-boiling point starting material makes it possible to separate an optically active alcohol from the reaction mixture with high purity in high yield by means of a simple purification step taking advantage of a difference in physical properties.

REFERENCES:
patent: 4665029 (1987-05-01), Iwai et al.
patent: 5032523 (1991-07-01), Amano et al.
patent: 5047346 (1991-09-01), Kitazume et al.
patent: 5189204 (1993-02-01), Kitazumo et al.
patent: 5256569 (1993-10-01), Yoshida et al.

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