Process for producing optically active 2-phenoxypropionic acid

Details Process for producing optically active 2-phenoxypropionic acid Process for producing optically active 2-phenoxypropionic acid

1988-04-13

1989-02-07

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C07C 5912

Patent

active

048033014

ABSTRACT:
There is provided a process for producing an optically active 2-phenoxypropionic acid, which comprises allowing an optically active lactic ester represented by the following formula (I) to react with a phenol represented by the following formula (II) in the copresence of a reagent A and a reagent B defined below to form an optically active 2-phenoxypropionic ester represented by the following formula (III), and liberating an optically active 2-phenoxypropionic acid represented by the following formula (IV) from the optically active 2-phenoxypropionic ester: ##STR1## wherein R.sup.1 represents a group to form a monovalent ester, which can be eliminated from the compound (III) under weakly basic to acidic conditions and R.sup.2 represents a hydrogen atom or 1 to 5 substituents which do not interfere in the reaction between the compounds (I) and (II); a reagent A being at least one compound selected from the group consisting of trialkylphosphine, trialkylphosphite, triarylphosphine and triarylphosphite; and a reagent B being at least one compound selected from the group consisting of dialkylazodicarboxylate and diarylazodicarboxylate.

REFERENCES:
patent: 2509772 (1950-05-01), Leaper
patent: 2805251 (1957-09-01), Marshall
patent: 4153803 (1979-05-01), Thiele
patent: 4173709 (1979-11-01), Metivier
patent: 4532346 (1981-07-01), Rehn
patent: 4760172 (1988-07-01), Tai

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