Process for producing optically active 2-hydroxycycloalkanecarbo

Details Process for producing optically active 2-hydroxycycloalkanecarbo Process for producing optically active 2-hydroxycycloalkanecarbo

1992-02-19

1993-06-01

Naff, David M.

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

435832, 435849, 435852, 435873, 435879, 435880, C07C 2914

Patent

active

052159191

ABSTRACT:
A (1R,2S)-2-hydroxycycloalkanecarboxylic acid ester is efficiently and selectively produced by microbial asymmetric reduction of a 2-oxocycloalkanecarboxylic acid ester with a bacterial strain or its processed material.

REFERENCES:
Shen G-J, J. Chem. Soc. Chem. Commun: 677-9 (1990).
Seebach et al., Helvetica Chimica Acta., vol. 70 (1987) pp. 1605-1615.
Buisson et al., Tetrahedron Letters, vol. 17, No. 23 pp. 2631-2634 (1986).
Deol et al., Aust. J. Chem. 1976, 29, pp. 2459-2467.

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