Process for producing optically active 2-hydroxy-4-arylbutyric a

Details Process for producing optically active 2-hydroxy-4-arylbutyric a Process for producing optically active 2-hydroxy-4-arylbutyric a

1999-06-29

2000-07-11

Barts, Samuel

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

562470, C07C 6976

Patent

active

060875267

ABSTRACT:
Provided is an industrially useful process for producing an optically active 2-hydroxy-4-arylbutyric acid or its ester. An optically active acyloxysuccinic anhydride is reacted with an aromatic compound in the presence of a Lewis acid to produce an optically active 2-acyloxy-4-oxo-4-arylbutyric acid. The 2-acyloxy-4-oxo-4-arylbutyric acid is converted to an optically active 2-acyloxy-4-arylbutyric acid through catalytic reduction. The 2-acyloxy-4-arylbutyric acid is hydrolyzed in the presence of an acid or an alkali to produce an optically active 2-hydroxy-4-arylbutyric acid. The 2-hydroxy-4-arylbutyric acid is reacted with an alcohol in the presence of an acid to produce an optically active 2-hydroxy-4-arylbutyric acid ester.

REFERENCES:
Patent Abstracts of Japan, vol. 15, No. 472 (C-0889), Nov. 29, 1991, JP-A-03 200739, Sep. 2, 1991.
Patent Abstracts of Japan, vol. 18, No. 75 (C-1163), Feb. 8, 1994, JP-A-05 286890, Nov. 2, 1993.
Chemical Abstracts 1967:16727, Cohen et al, Casoline printout month unavailable.

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