Process for producing nucleosides

Details Process for producing nucleosides Process for producing nucleosides

1993-05-04

1995-01-24

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435 88, 435193, 435194, 4352525, 435832, C12P 1938, C12P 1940, C12N 120

Patent

active

053842510

ABSTRACT:
The present invention concerns a process for producing nucleosides by carrying out the reaction of a base donor, a saccharide residue donor and a phosphoric acid donor by the use of an enzyme preparation containing nucleoside phosphorylase, thereby forming an N-glycosidic bond between the base moiety of the base donor and the saccharide moiety of the saccharide residue donor, which comprises using, as the enzyme preparation containing nucleoside phosphorylase, a preparation derived from the cells of one or more kinds of microorganisms belonging to thermophiles of the genus Bacillus and having high nucleoside phosphorylase activity per unit cell weight.

REFERENCES:
patent: 4331762 (1982-05-01), Nakajima et al.
patent: 5306629 (1994-04-01), Yamamoto et al.
JPO Abs (J56-8696) Abs Pub. Apr. 21, 1981, Udagawa et al.
JPO Abs (J61-104795) Abs Pub Sep. 30, 1986 Tsunemi et al.
JPO Abs (J60-239495) Abs Pub Apr. 25, 1986 Kobayashi et al.
Nakashima et al., Patent Abstracts of Japan 56-148289 (Nov. 1981).
Saunders et al., Chemical Abstracts 56941r (1969).

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