Process for producing nucleoside derivatives

Details Process for producing nucleoside derivatives Process for producing nucleoside derivatives

1998-07-30

2000-10-03

Prats, Francisco

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435 89, 435 85, 435 72, 435197, 435 84, C12P 1938

Patent

active

061271527

ABSTRACT:
There is disclosed a process for producing a nucleoside derivative of the formula [I]: ##STR1## characterized by contacting 2',3',5'-O-triacylribonucleoside derivative of the formula [II]: ##STR2## with an ester hydrolase: (i) capable of regio-selectively deacylating the acyl group at 5'-O-position in the formula [II] above, and

REFERENCES:
Enzymatic Regioselective Deacylation of 2',3',5'-Tri-O-Acylribo-Nucleosides: Enzymatic Synthesis of 2',3',-Di-o-Acylribonucleosides, Haribansh K. Singh et al., Tetrahedron Letter, vol. 34, pp. 5201-5204 (1993).

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