Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...
Patent
1979-04-30
1980-09-30
Tanenholtz, Alvin E.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing heterocyclic carbon compound having only o, n, s,...
435886, 2602393T, C12P 1712
Patent
active
042256747
ABSTRACT:
A new subspecies of Streptomyces nigellus Prokop, designated Streptomyces nigellus Prokop subsp. africanus Huang subsp. nov. ATCC 31496, when propagated under aerobic conditions in aqueous nutrient media, produces a mixture of antibiotics. One of these antibiotics is the known macrolide antibiotic cirramycin A; the ansamycin antibiotic is an analogue of protostreptovaricin and the structure has been established as 21-hydroxy, 25-demethyl, 25-methylthioprotostreptovaricin I.
REFERENCES:
patent: 3094461 (1963-06-01), Prokop
patent: 3116202 (1963-12-01), Dietz et al.
patent: 3880858 (1975-04-01), Oshida et al.
Handbook of Microbiology, vol. III, CRC Press, p. 202, (1973).
Celmer Walter D.
Cullen Walter P.
Huang Liang H.
Oscarson John R.
Shibakawa Riichiro
Pfizer Inc.
Tanenholtz Alvin E.
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