Process for producing natural heparan sulphate and dermatan sulp

Details Process for producing natural heparan sulphate and dermatan sulp Process for producing natural heparan sulphate and dermatan sulp

1986-03-10

1988-11-08

Rollins, John W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 21, 514822, A61K 31725, C08B 3710

Patent

active

047834471

ABSTRACT:
A process for producing natural heparan sulphate and dermatan sulphate for mixtures of proteoglycans from the aorta, myocardium and particularly vascularized organs, based on a series of precipitation and purification steps which enable the protein part of the proteoglycan to be eliminated and the two products to be obtained in substantially pure form, without any chemical or enzymatic degradation.
When administered orally or parenterally, the heparan sulphate obtained exerts activation effects on antithrombin III and on the fibrinolytic process.
The dermatan sulphate obtained exerts an inhibiting effect on Factor Xa and also possesses the property of activating the fibrinolytic effect of heparan sulphate.

REFERENCES:
patent: 3862003 (1975-01-01), Okuyama et al.
patent: 4243582 (1981-01-01), Spilburg et al.

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