Process for producing N.sup.4 -acyl-5'-deoxy-5-fluorocytidine co

Details Process for producing N.sup.4 -acyl-5'-deoxy-5-fluorocytidine co Process for producing N.sup.4 -acyl-5'-deoxy-5-fluorocytidine co

1993-12-16

1995-09-26

Robinson, Douglas W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 285, 536 2851, C07H 100

Patent

active

054534976

ABSTRACT:
A novel process for producing derivatives of the anti-tumor agent N.sup.4 -acyl-5'-deoxy-5-fluorocytidine using the novel 5'-deoxy-5-fluoro-N.sup.4, 2'-0,3'-0-triacylcytidine derivatives as intermediates is provided.
5-Deoxy-1,2,3-tri-0-acyl-.beta.-D-ribofuranoside is reacted with 5-fluorocytosine to produce 5'-deoxy-2',3'-di-0-acyl-5-fluorocytidine, followed by acylation, to produce the novel intermediate 5'-deoxy-5-flouro-N.sup.4,2'-0,3'-0-triacylcytidine. The acyl radicals of this intermediate are selectively de-0-acylated to obtain N.sup.4 -acyl-5'-deoxy-5-fluorocytidine derivatives. From fluorocytosine, N.sup.4 -acyl-5'-deoxy-5-fluorocytidine derivatives can be obtained through few steps in high yield, an in satisfactory purity.

REFERENCES:
patent: 4966891 (1990-10-01), Morio Fujiu et al.

Affiliated with

Also associated with

Rating

Process for producing N.sup.4 -acyl-5'-deoxy-5-fluorocytidine co does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for producing N.sup.4 -acyl-5'-deoxy-5-fluorocytidine co, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for producing N.sup.4 -acyl-5'-deoxy-5-fluorocytidine co will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1552534