Process for producing N.sub.1 -(.alpha.-butyrolactone- and N.sub

Details Process for producing N.sub.1 -(.alpha.-butyrolactone- and N.sub Process for producing N.sub.1 -(.alpha.-butyrolactone- and N.sub

1973-07-16

1976-05-04

Coughlan, Jr., Paul M.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424251, C07D23954

Patent

active

039547604

ABSTRACT:
A process for producing N.sub.1 -(.alpha.-butyrolactone)- and N.sub.1 -(.alpha.-valerolactone)-5-substituted uracils of the formula: ##SPC1##
Wherein R.sub.1 is hydrogen, methyl, a trihalomethyl or a halogen; R.sub.2 is hydrogen or an alkyl, n = 1 or 2, characterized in that a bis(trimethylsilyl)-5-substituted uracil of the formula: ##SPC2##
Wherein R.sub.1 is hydrogen, methyl, a trihalomethyl or a halogen, is treated with an .alpha.-bromolactone of the formula: ##SPC3##
Wherein R.sub.2 is hydrogen or an alkyl, n = 1 or 2. The reaction is conducted at a temperature ranging from 80.degree. to 160.degree.C. From the reaction mixture thus obtained there is distilled off the resulting trimethylbromosilane formed during the reaction, and the reaction mixture is treated with a lower aliphatic alcohol.

REFERENCES:
patent: 3635946 (1972-01-01), Giller et al.
Hiller et al., Analogs of Pyrimidines Nucleosides, Chemistry of Heterocyclic Compounds, Vol. 4, No. 3, May-June 1968, pp. 412-413.

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