Process for producing N-protected-.alpha.-L-aspartyl-L-phenylala

Details Process for producing N-protected-.alpha.-L-aspartyl-L-phenylala Process for producing N-protected-.alpha.-L-aspartyl-L-phenylala

1985-12-10

1987-07-14

Kight, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548478, 549273, 549477, 560 38, 562445, 562571, 426548, C07D30722

Patent

active

046804030

ABSTRACT:
The invention relates to a process for producing N-protected-.alpha.L-aspartyl-L-phenylalanine methyl ester, which comprises esterifying L-phenylalanine with methanol in the presence of a strong acid catalyst, adding, to the resulting solution, an aqueous alkaline solution to neutralize the acid catalyst and a water-immiscible organic solvent to extract the free L-phenylalanine methyl ester thus formed, collecting the organic layer, and reacting the L-phenylalanine methyl ester dissolved in said collected organic layer with N-protected-L-aspartic anhydride.

REFERENCES:
patent: 3786039 (1974-01-01), Ariyoshi et al.
patent: 3833553 (1974-09-01), Ariyoshi et al.
patent: 4550180 (1985-10-01), Takemoto et al.

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