Process for producing n-acyl-acyloxy aromatic amines

Details Process for producing n-acyl-acyloxy aromatic amines Process for producing n-acyl-acyloxy aromatic amines

1985-03-12

1987-05-12

Lone, Warren B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560144, C07C 69017

Patent

active

046652167

ABSTRACT:
A process is provided for producing N-acyl-acyloxy aromatic amine, such as 4-acetoxyacetanilide by reacting a hydroxy-aromatic ketoxime with a carboxylic acid anhydride, e.g. acetic anhydride, in the presence of phosphoric or oxalic acid as a Beckmann rearrangement catalyst. Preferably the ketoxime is prepared by reacting a hydroxy aromatic ketone such as 4-hydroxyacetophone with a hydroxyl amine salt, and the ketone is obtained by the Fries rearrangement of a phenolic ester, e.g. phenyl acetate or the Friedel-Crafts acylation of a phenolic compound, e.g. phenol, with an acylating agent, e.g. acetic acid.

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